Radiotherapy

Cancer is the leading cause of mortality in developed countries and the second leading cause in developing countries, trailing cardiovascular diseases, and accounting for 8.2 million deaths in 2012 alone. Estimates expect an increase in cancer incidence from 14 million in 2012 to up to 22 within the next two decades.[1]

Radiotherapy (RT) showed itself, very early, at the beginning of the 20th century, to be a beneficial and very important instrument in the treatment of cancer. Moreover about 50 - 60% of all cancer patients will receive radiotherapy during the course of their disease, either in a curative or in a palliative intent[2].

Improvements and technological innovations of radiation treatment machines and of imaging modalities have led to an increase of accuracy and precision of radiation delivery. Highly innovative and modern techniques, such as stereotactic radiosurgery and intensity modulated radiotherapy, have been developed and are now a part of our daily routine. Unfortunately and despite all of the changes and advances in the technical part, their utilization in our clinical practice, has not always been accompanied by a high level of evidence [3, 4]. However, our daily decision making needs to be based on the highest level of evidence and this is achieved only through well designed, properly conducted and analyzed, clinical trials.

The goal of the project is to evaluate all clinical trials that utilize radiotherapy, regardless of phase. We have manually classified over 6000 registered trials according to evaluated diseases, interventions, primary sponsors and source of monetary support.

Final results is expected by end of 2016.

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer Journal international du cancer 2010, 127(12):2893-2917.
  2. Delaney G, Jacob S, Featherstone C, Barton M: The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005, 104(6):1129-1137.
  3. Olsen DR, Bruland OS, Frykholm G, Norderhaug IN: Proton therapy - a systematic review of clinical effectiveness. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007, 83(2):123-132.
  4. Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M, De Neve W: Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. The Lancet Oncology 2008, 9(4):367-375.